基本信息

中文別名:炔雌醇;17α-乙炔-1,3,5-(10)-雌甾三烯-1,17-二醇;炔雌醚;乙炔雌二醇;3-羥基-19-去甲-17Α-甾-1,3,5(10)-三烯-20-炔-17-醇;炔雌酮;17A-炔雌醇;17Α-乙炔-1,3,5-(10)-雌甾三烯-3,17Β-二醇
英文別名:17a-ethynyl-1,3,5(10)-estratriene-3,17b-diol; 17alpha-ethynyl-3,17-dihydroxy-delta-(sup1,3,5)-estratriene; eticyclin; eticyclol; etinestrol; etinestryl; feminone; ginestrene; inestra; linoral; lynoral; menolyn; neo-estrone; novestrol; oradiol; orestralyn; palonyl; perovex; primogyn; primogyn c(or m); progynon c; roldiol; spanestrin; ylestrol; 17alpha-Ethynyl-3-hydroxy-1,3,5(10)-estratrien-17beta-ol; 17-ethynyl estradiol; 19-nor-17alpha-pregna-1,3,5(10)-trien-20-yne-3,17,diol; 19-Norpregna-1,3,5(10)-trien-20-yne-3,17-diol, (17alpha)-; 3,17beta-dihydroxy-17alpha-ethynyl-1,3,5(10)-estratriene; amenoron; anovlar; diognat-e; diogyn-e; chee-o-genf; dyloform; EE; esteed; estigyn; estinyl; Estone; estoral (orion); estra-1,3,5(10)-triene-3,17beta-diol, 17alpha-ethynyl-; estroals; ethidol; ethinoral; ethinyloestradiol; Ethynyl estradiol;

乙炔雌二醇物理化學(xué)性質(zhì)

密度：1.21g/cm³
熔點(diǎn)： 182-183℃
沸點(diǎn)： 457.2°C at 760 mmHg
閃點(diǎn)： 211.2°C
蒸汽壓： 3.74E-09mmHg at 25°C

乙炔雌二醇生產(chǎn)方法

由雌酮（C18H22O2，[53-16-7]）乙炔化而得：將甲苯異丁醇、氫氧化鉀及異丁醇加熱回流共沸脫水8h，加四氫呋喃，于25-40℃下通入乙炔至需要量度。再加雌酮四氫呋喃溶液，在5-10℃繼續(xù)通乙炔12h。用30%硫酸于40℃以下調(diào)節(jié)微酸性，減壓回收四氫呋喃。用水蒸氣蒸餾除去殘余溶液，冷卻，過濾，用水洗至中性，在80℃干燥，得乙炔雌二醇粗品。經(jīng)乙醇重結(jié)晶，活性炭脫色即為成品。收率85%。

乙炔雌二醇儲運(yùn)特性

本品應(yīng)密封于4℃干燥保存。