基本信息

中文別名:16alpha-甲基-11beta,17alpha,21-三羥基-9alpha-氟孕甾-1,4-二烯-3,20-二酮-21-醋酸酯;醋酸地塞米松;21α-乙酰氧基-9α-氟-11β,17α-二羥基-16α-甲基孕甾-1,4-二烯-3,20-二酮;9α-氟-11β,17α,21-三羥基-16α-甲基孕甾-1,4-二烯-3,20-二酮-21-醋酸酯;醋酸氟甲強的松龍;醋酸氟美松;醋酸甲氟烯索;地塞米松醋酸酯
英文別名:1,4-PREGNADIEN-9-ALPHA-FLUORO-16-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-ACETATE; 9a-fluoro-16a-methyl-11b,17a,21-trihydroxy-1,4-pregnadiene-3,20-dione-21-acetate; 9 ALPHA-FLUORO-11 BETA,17 ALPHA,21-TRIHYDRO-16 ALPHA-METHYLPREGNA-1,4-DIENE-3,20-DIONE-21-ACETATE; 9ALPHA-FLUORO-16ALPHA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE-21-ACETATE; 9-ALPHA-FLUORO-16-ALPHA-METHYL-11-BETA,17-ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE ACETATE; 9ALPHA-FLUORO-16ALPHA-METHYLPREDNISOLONE-21-ACETATE; DEXAMETHASON ACETATE; dexamethasone-17-acetate; DEXAMETHASONE 21-ACETATE; DEXAMETHASONE ACETATE; PREDNISOLONE F ACETATE; ,(11beta,16alpha)-; 16alpha-Methyl-9alpha-fluoroprednisolone 21-acetate; 20-dione,21-(acetyloxy)-9-fluoro-11,17-dihydroxy-16-methyl-pregna-4-diene-3; 20-dione,9-fluoro-11-beta,17,21-trihydroxy-16-alpha-methyl-pregna-4-diene-3; 9alpha-Fluoro-16alpha-methylprednisolone acetate; 9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione21-acetate; 9-Fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl acetate; 9-fluoro-11-beta,17,21-trihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione; 9-Fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-acetate

醋酸地塞米松物理化學(xué)性質(zhì)

熔點 215-227℃
折射率 87 ° (C=1, Dioxane)
外觀性狀 白色或類白色結(jié)晶性粉末，無臭，味微苦
溶解性 丙酮中易溶，在甲醇或乙醇中溶解，在乙醇或氯仿中略溶，在乙醚中極微溶解，在水中不溶 

醋酸地塞米松產(chǎn)品用途

倍他米松、地塞米松磷酸鈉的中間體。用于抗炎和抗過敏，適用于類風(fēng)濕性關(guān)節(jié)炎和其他膠原性疾病等。

醋酸地塞米松生產(chǎn)方法

可用16α,17α-環(huán)氧孕甾-4-烯-3,11,20-三酮（即16α,17α-環(huán)氧-11-酮基黃體酮）經(jīng)（3-位、20-位酮基）縮酮化、（11-位酮基）還原、消除[9（11）-位脫水形成雙鍵]、（環(huán)氧基與甲基溴化鎂）加成并水解（形成17α-羥基，16β-甲基）、水解（脫除乙二醇）得17α-羥基-16β-甲基孕甾-4,9（11）-二烯-3,20-二酮，然后經(jīng)（4、5-位）脫氫（形成雙鍵）、（21-位）碘化、（21-位碘經(jīng)乙酰氧基）置換，[9（11）-位雙鍵與次溴酸]加成、[9（11）-位]環(huán)氧化、9（11）位氟化氫加成后制得該品。